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Moreover, the ERK1/2 signaling pathway is activated by S100A9, promoting tumor immune escape through upregulation of PD-L1 expression, which further enhances the immunosuppressive environment [149]

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The key inflammatory markers in brain injury include interleukin-1 beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and interleukin-6 (IL-6)

Doing so can introduce bacteria and increase the risk of localized or systemic infections

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Excessive Caffeine Moderate coffee intake is generally fine, but overconsumption of caffeine raises cortisol levels and contributes to oxidative stress